BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Pharmacology - ECPv6.11.1//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-ORIGINAL-URL:/pharm X-WR-CALDESC:Events for Pharmacology REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:America/New_York BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20250309T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20251102T060000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=America/New_York:20250909T160000 DTEND;TZID=America/New_York:20250909T170000 DTSTAMP:20250523T130013 CREATED:20240611T151411Z LAST-MODIFIED:20240611T151411Z UID:10000953-1757433600-1757437200@www.med.unc.edu SUMMARY:Fall Steelman Distinguished Lecturer\, Lisa M. Coussens of Oregon Health & Science University presents DESCRIPTION:Lisa M. Coussens\, Ph.D.\, FAACR\, FAIO\nHildegard Lamfrom Endowed Chair in Basic Science\nProfessor and Chairwoman\, Department of Cell\, Developmental & Cancer Biology\nDeputy Director for Basic & Translational Research\, Knight Cancer Institute\nOregon Health & Science University \nSeminar title:聽TBD \nThis seminar will be in 1131 Bioinformatics \nPlease join us and show support for our seminar speakers!\n(For those unable to attend\, a zoom link is available upon request to聽Mimi Baltz.) \nHost: Steelman Committee (Mike Emanuele\, Kirsten Bryant\, Kevin Pruitt\, John Morris) \nAbout Dr. Coussens鈥� research: The Coussen鈥檚 lab is 鈥渋nterested in understanding the molecular and cellular mechanisms that regulate leukocyte recruitment into neoplastic tissue\, and the subsequent regulation those leukocytes exert on evolving cancer cells.鈥� ~ Coussen鈥檚 Lab website URL:/pharm/event/fall-steelman-distinguished-lecturer-lisa-m-coussens-of-oregon-health-science-univeristy-presents/ LOCATION:1131 Bioinformatics\, 130 Mason Farm Rd\, Chapel Hill\, North Carolina\, 27514\, United States CATEGORIES:Pharmacology Seminars ATTACH;FMTTYPE=image/jpeg:/pharm/wp-content/uploads/sites/930/2024/06/Lisa-Coussens-250-3.jpg ORGANIZER;CN="Mimi Baltz":MAILTO:my.le@unc.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20250916T160000 DTEND;TZID=America/New_York:20250916T170000 DTSTAMP:20250523T130013 CREATED:20250108T202503Z LAST-MODIFIED:20250108T202503Z UID:10000980-1758038400-1758042000@www.med.unc.edu SUMMARY:Dr. Kim Green of the University of California\, Irvine presents DESCRIPTION:Kim Green\, PhD\nProfessor\nDepartment of Neurobiology and Behavior\nUniversity of California\, Irvine \nSeminar title: 鈥淭BD鈥� \nPlease join us and show support for our seminar speakers!\n(For those unable to attend\, a zoom link is available upon request to聽Mimi Baltz.) \nHost: Leon Coleman \nDr. Green has been a pioneer in two areas in the Alzheimer鈥檚/neurobiology research field: \n1) He has made pioneering discoveries regarding the role of microglia in Alzheimer鈥檚 disease and healthy neurobiology. He has made many contributions\, including identifying the colony stimulated factor receptor 1 (CSFR1) as a required receptor for microglial survival. Currently CSFR1 antagonists are broadly used in the field to study the impacts of microglial depletion on brain function. \n2) The development of mouse models for Alzheimer鈥檚 disease. Dr. Green is a PI of the MODEL-AD consortium\, which has developed many of the most widely used mouse models for Alzheimer鈥檚 disease. The MODEL-AD consortium has also recently developed mouse models for late onset/sporadic AD\, which will be invaluable for the field. \n~ https://faculty.sites.uci.edu/kimgreen \n聽 URL:/pharm/event/dr-kim-green-of-the-university-of-california-irvine-presents/ LOCATION:1131 Bioinformatics\, 130 Mason Farm Rd\, Chapel Hill\, North Carolina\, 27514\, United States CATEGORIES:Pharmacology Seminars ATTACH;FMTTYPE=image/jpeg:/pharm/wp-content/uploads/sites/930/2025/01/IMG_7771_Kim_Green-250.jpg ORGANIZER;CN="Mimi Baltz":MAILTO:my.le@unc.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20250930T160000 DTEND;TZID=America/New_York:20250930T170000 DTSTAMP:20250523T130013 CREATED:20250428T135117Z LAST-MODIFIED:20250428T135117Z UID:10001012-1759248000-1759251600@www.med.unc.edu SUMMARY:Dr. Shaun Olsen of the University of Texas San Antonio presents DESCRIPTION:Shaun Olsen\, PhD\nProfessor\nDepartment of Biochemistry & Structural Biology\nUniversity of Texas\, San Antonio \nSeminar title:聽TBD \nThis seminar will be in 1131 Bioinformatics \nPlease join us and show support for our seminar speakers!\n(For those unable to attend\, a zoom link is available upon request to聽Mimi Baltz.) \nHost: Rob Nicholas \n聽 \nThe research in the Olsen laboratory focuses on mechanisms of molecular recognition in protein-protein interactions and on the structural enzymology of proteins essential for cellular function. The majority of his efforts are focused on understanding how enzymes in the ubiquitin (Ub) conjugation cascade (E1\, E2\, and E3) function together to conjugate Ub to cellular proteins. Post-translational modification of proteins by Ub is a means of regulating fundamental cellular processes including cell cycle control\, DNA repair\, signal transduction\, and immunity. The importance of understanding how the Ub system works is underscored by the fact that dysregulation of Ub signaling is implicated in a number of human disorders and that the pathway is a validated target for therapeutic intervention in cancer. He employs a multidisciplinary approach that includes X-ray crystallography\, single particle cryo-EM\, enzymology\, and a variety of biochemical and biophysical techniques. (from his web site-聽 ~https://directory.uthscsa.edu/academics/profile/olsens) URL:/pharm/event/dr-shaun-olsen-of-the-university-of-texas-san-antonio-presents/ LOCATION:1131 Bioinformatics\, 130 Mason Farm Rd\, Chapel Hill\, North Carolina\, 27514\, United States CATEGORIES:Pharmacology Seminars ATTACH;FMTTYPE=image/jpeg:/pharm/wp-content/uploads/sites/930/2025/04/olsen_shaun_250.jpg ORGANIZER;CN="Mimi Baltz":MAILTO:my.le@unc.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20251007T160000 DTEND;TZID=America/New_York:20251007T170000 DTSTAMP:20250523T130013 CREATED:20250106T212053Z LAST-MODIFIED:20250106T212346Z UID:10000977-1759852800-1759856400@www.med.unc.edu SUMMARY:Dr. Sara Buhrlage of the Dana-Farber Cancer Institute presents DESCRIPTION:Sara Buhrlage\, PhD\nAssociate Professor\nDepartment of Biological Chemistry and Molecular Pharmacology\nHarvard University Medical School and the\nDana-Farber Cancer Institute \nSeminar Title: 鈥淭BD鈥� \nPlease join us and show support for our seminar speakers!\n(For those unable to attend\, a zoom link is available upon request to聽Mimi Baltz.) \nHosts: Mike Emanuele and Nick Brown \nFrom the Buhrlage Lab website: 鈥淥ur mission is to revolutionize our ability to interrogate deubiquitinase (DUB) biology\, validate DUBs as therapeutic targets\, and develop small molecule-based ligands suitable for clinical development. To accomplish this\, we have established an integrated DUB-centric platform comprised of DUB-targeted libraries with novel scaffolds and chemotypes and a suite of established and novel biochemical and chemoproteomic assays to profile compound activity and selectivity\, as well as expertise in DUB medicinal chemistry\, structural biology\, computational chemistry\, and functional annotation.鈥� ~ https://buhrlagelab.dana-farber.org/ URL:/pharm/event/dr-sara-buhrlage-of-the-dana-farber-cancer-institute-presents/ LOCATION:1131 Bioinformatics\, 130 Mason Farm Rd\, Chapel Hill\, North Carolina\, 27514\, United States CATEGORIES:Pharmacology Seminars ATTACH;FMTTYPE=image/jpeg:/pharm/wp-content/uploads/sites/930/2025/01/7884248-Sara-Buhrlage-250.jpg ORGANIZER;CN="Mimi Baltz":MAILTO:my.le@unc.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20251014T160000 DTEND;TZID=America/New_York:20251014T170000 DTSTAMP:20250523T130013 CREATED:20250428T141414Z LAST-MODIFIED:20250428T141414Z UID:10001013-1760457600-1760461200@www.med.unc.edu SUMMARY:Dr. Marta Filizola DESCRIPTION:Marta Filizola\, PhD\nProfessor of Pharmacological Sciences and Neuroscience\nDean of the Graduate School of Biomedical Sciences\nIcahn School of Medicine at Mount Sinai\n\nSeminar title: TBD\n\nThis seminar will be in 1131 Bioinformatics\n\nPlease join us and show support for our seminar speakers!\n\n(For those unable to attend\, a zoom link is available upon request to聽Mimi Baltz.) \nHost: Yinglong Miao \n\n聽 \nFrom the Filizola website: Our research program aims to obtain rigorous mechanistic insights into the structure\, dynamics\, and function of important classes of membrane proteins and prominent drug targets\, including G protein-coupled receptors (GPCRs)\, transporters\, channels\, and beta3 integrins. Understanding the molecular mechanisms underlying the complex biological functions of these proteins has direct translational relevance because it informs the rational discovery of potentially improved therapeutic agents. To this end\, we use several computational structural biology tools and rational drug design approaches\, ranging from molecular modeling\, bioinformatics\, cheminformatics\, molecular dynamics simulations\, metadynamics\, free-energy perturbations\, artificial intelligence/machine learning\, etc. \nThe strength of our research relies on the integration of state-of-the-art computational methodologies with collaborative experimental approaches to provide valuable mechanistic interpretations at the molecular level of the ligand-induced transmission of the signal to the inner side of the cell membrane. While our research is driven by the exploration and improvement of computational methods to characterize generalizable mechanisms of molecular recognition and signal transduction\, we are excited by the contributions that our computational and modeling efforts make to the experimental field through the generation of new testable hypotheses to support the discovery of improved therapies. (~ https://filizolalab.org) \n聽 URL:/pharm/event/dr-marta-filizola/ LOCATION:1131 Bioinformatics\, 130 Mason Farm Rd\, Chapel Hill\, North Carolina\, 27514\, United States CATEGORIES:Pharmacology Seminars ATTACH;FMTTYPE=image/jpeg:/pharm/wp-content/uploads/sites/930/2025/04/marta-filizola-250.jpg ORGANIZER;CN="Mimi Baltz":MAILTO:my.le@unc.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20251111T160000 DTEND;TZID=America/New_York:20251111T170000 DTSTAMP:20250523T130013 CREATED:20250515T161714Z LAST-MODIFIED:20250515T161714Z UID:10001014-1762876800-1762880400@www.med.unc.edu SUMMARY:Dr. Kenneth A. Jacobson from the National Institutes of Health presents DESCRIPTION:Kenneth A. Jacobson\, PhD\nJohn W. Daly Distinguished Scientist\nSenior Investigator\nLaboratory of Bioorganic Chemistry\nNIDDK\, National Institutes of Health \nSeminar Title:聽鈥淎ction of Nucleosides and Nucleotides at Purinergic and Non-Purinergic Drug Targets鈥� \nPlease join us and show support for our seminar speakers!\n(For those unable to attend\, a zoom link is available upon request to聽Mimi Baltz.) \nHost: Yinglong Miao \nDr. Jacobson is an established medicinal chemist with interests in the structure and pharmacology of receptors and in developing drugs that act as agonists or antagonists of G protein-coupled receptors (GPCRs). His current focus is on receptors for purines\, encompassing both adenosine receptors and P2 receptors\, which are activated by ATP\, UTP and other extracellular nucleotides. His lab has taken an interdisciplinary approach to studying the chemical and biological aspects of these receptors. They have used convergent modeling\, mutagenesis and structure activity approaches to gather information about the three-dimensional structure of the receptors and its relationship to binding and activation functions. \nhttps://www.niddk.nih.gov/about-niddk/staff-directory/biography/jacobson-kenneth \nFlyer [pdf] URL:/pharm/event/dr-kenneth-a-jacobson-from-the-national-institutes-of-health-presents-2/ LOCATION:1131 Bioinformatics\, 130 Mason Farm Rd\, Chapel Hill\, North Carolina\, 27514\, United States CATEGORIES:Pharmacology Seminars ATTACH;FMTTYPE=image/jpeg:/pharm/wp-content/uploads/sites/930/2024/12/Jacobson-Kenneth_250x250.jpg ORGANIZER;CN="Mimi Baltz":MAILTO:my.le@unc.edu END:VEVENT END:VCALENDAR