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Research: Determining the Role of DVL3 in regulating the activity of immunomodulatory genes and immune recruitment to tumors

• Below Left: Nuclear DVL3 binds to immune-related genes in human breast cancer cells
  • Chromatin immunoprecipitation (ChIP) sequencing analysis on MDA-MB-468 and MCF7 cells showed that nuclear DVL3 binds to a plethora of immune genes, however, how that affects tumor growth in immunocompetent mice is still unknown.
• Below Right: Discovery of DVL3-regulated genes that affects immune activity in tumors
  • This project will evaluate the expression of immune-related genes in mouse mammary carcinoma cells lines with and without DVL3 knockdown (KD) and elucidate the effects of DVL3 over immune infiltration by tranplanting the mouse KD cells into immunocompetent mice.