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Research: Discovery of broad transcriptional influence of nuclear DVL1

• Below left: Nuclear DVL1 alters transcription
  • Top: DiVenn-force directed graph with parental nodes (DVL1 mutants) and child nodes(unique and overlapping genes). Upregulated genes are shown in red, downregulated genes in blue, and genes that are multi-direction in yellow.
  • Bottom: Network graph with parent (affected pathways) terms and child (gene) nodes distributed between different cellular compartments. AI prediction of most affected complex due to DVL1 modulation shown at the bottom of figure
• Below Middle: Modulation of DVL1 alters transcription alters nuclear protein-protein interactions
  • Network graph of DVL1,2,3 (highlighted in yellow) protein interactions with associated protein names in each node
• Below Right: Integrative multi-omic analysis of DVL1 transcriptional regulation
  • Pathwork network graph of interactive omic analysis in cells with modulated DVL1 expression.The parental pathway term is shown in colored clusters and child nodes in its associated clusters.