Dr. Bryan Roth and his lab previously developed synthetic GPCRs called DREADDs. This technology has in turn laid the foundation for a new technology, PAGERs, which has an innovative approach to controlling cell activity. 听DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) are synthetic GPCRs that are activated in cells or transgenic animals only when researchers administer a specific drug. The new technology, called PAGERs (Programmable Antigen-gated G-protein-coupled Engineered Receptors) provide modular, customizable G-protein-coupled receptors for cell-signalling studies.听 The PAGERs modular system developed by Alice Ting of Sanford) and Yulong Li (Peking University), builds on Roth鈥檚 existing DREADDs technology.听 Ting’s and Li’s paper 鈥�Synthetic GPCRs for programmable sensing and control of cell behaviour,鈥� was published in Nature in December 2024. The Nature article by Stephanie Melchor highlighting PAGERs includes an interview with Bryan Roth: 听 