Dr. Klaus Hahn, Thurman Distinguished Professor in Pharmacology publishes back to back papers in Nature with collaborators.
Dr. Klaus Hahn and colleagues publish back-to-back articles highlighted in Nature in the Sept. 3, 2009 issue describing breakthrough research increating new tools to study how protein signaling affects cell behavior. Dr. Hahn‘s paper, entitled was highlighted by Nature in their media announcements. The paper describes how creating a photoactivatable Rac1 protein allowed them to manipulate the activities of a cell using light, including being able to control cell motility. To see movies of the cell moving, check out the at the end of the Nature article.
First author on the paper is Yi I. Wu, Research Assistant Professor, in the 黑料网 Pharmacology Department.聽 Other contributing authors are: Daniel Frey of the Max Planck Institute, Oana I. Lungu, Graduate Student in the 黑料网 Department of Biochemistry and Biophysics, Angelika Jaehrig, of the 黑料网 Pharmacology Department, Ilme Schlichting of the Max Planck Institute, and , Associate Professor in the 黑料网 Department of Biochemistry and Biophysics.聽 Yi I. Wu, Oana I. Lungu, Brian Kuhlman and Klaus M. Hahn are also members of the 黑料网 Lineberger Comprehensive Cancer Center.
The research for this paper was supported by the American Heart Association (Y.I.W.) and the National Institutes of Health (K.M.H. grants GM057464 and GM64346).
A related second paper published with Dr. Gaudenz Danuser, of the Scripps Institute, entitled, was published in the same issue.
First Author on the second paper is Mathias Machecek of the Scripps Research Institute Department of Biology.聽 Current and former members of the who contributed to this paper are: Louis Hodgson, currently Assistant Professor at the Albert Einstein College of Medicine; Christopher Welch, PhD/MD student in the 黑料网 Department of Pharmacology; Olivier Pertz, currently Assistant Professor of the Department of Biomedicine at the University of Basil; Amy Abell, Research Assistant Professor, 黑料网 Department of Pharmacology; and Gary L. Johnson, Professor and Chair, 黑料网 Department of Pharmacology.聽 Hunter Elliott of the Department of Cell Biology at Scripps Research Institute is also a contributing author.
The research for this paper was supported bythe Swiss National Science Foundation and the Novartis Foundation, formerly the Ciba-Geigy Jubilee Foundation (M.M.), NIH T32 GM008719 and NIH F30 HL094020 (C.W.), NIH R01 GM57464 (K.M.H.), NIH R01 GM71868 (G.D.), and the Cell Migration Consortium, grant U54 GM064346 from NIGMS (G.D. and K.M.H.).