BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Pharmacology - ECPv6.11.1//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-ORIGINAL-URL:/pharm X-WR-CALDESC:Events for Pharmacology REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:America/New_York BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20250309T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20251102T060000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=America/New_York:20250325T160000 DTEND;TZID=America/New_York:20250325T170000 DTSTAMP:20250530T103430 CREATED:20250310T204042Z LAST-MODIFIED:20250310T204133Z UID:10001000-1742918400-1742922000@www.med.unc.edu SUMMARY:Dr. Megan Agajanian of Stanford presents DESCRIPTION:Megan Agajanian\, PhD\nPostdoctoral Scholar\, Roel Nuuse Lab\nDepartment of Developmental Biology\nStanford University \nSeminar title: 鈥淭he dynamic role of TBX3 in 鈥淭he dynamic role of TBX3 in cancer and development鈥� \nLocation: 1131 Bioinformatics \nPlease join us and show support for our seminar speakers!\n(For those unable to attend\, a zoom link is available upon request to聽Mimi Baltz.) \nHost: Mike Emanuele \nMegan is a postdoc in Roul Nouse鈥檚 lab\, the person who first identified Wnt signaling in humans. She is a former Pharmacology student in the Emanuele Lab.聽 She has been funded by HHMI Gilliam and a K00 Award\, and was selected for the NSF-ASCB FRED Program. \nDr. Agajanian is interested in lineage plasticity and the signals that drive diverse cellular responses. Her postdoctoral work focuses on the dynamic role of TBX3 in breast cancer and mammary gland development. TBX3 mutations in the developing embryo result in Ulnar Mammary Syndrome\, which is characterized by incomplete mammary gland development. In contrast\, TBX3 is mutated in breast cancer and is associated with metastasis. Despite these critical roles of TBX3\, the role of patient mutations in breast cancer progression and the role of TBX3 in postnatal mammary gland expansion remain virtually unstudied. Using organoid and mouse models\, we have demonstrated TBX3 supports organoid growth and in vivo is required for mammary gland expansion during puberty. Interestingly\, previous work identified TBX3 as a lineage specific component of the Wnt transcriptional complex in colorectal cancer\, but it鈥檚 role in Wnt signaling in the mammary gland remains unknown. With her background in Wnt signaling interrogation\, in the future\, she aims to pursue her interest in lineage and context dependent regulators of this critical signaling cascade using a wide array of techniques\, including organoid models\, molecular biology\, proteomic\, and in vivo approaches. \n鈥淢y project focuses on TBX3 (T-Box Transcription Factor 3)\, one of the top ten mutated genes in breast cancer. TBX3 upregulation and loss of function mutations are identified in patients\, raising the question: is TBX3 a proto-oncogene or tumor suppressor? My work in the Nusse lab will define the role of TBX3 in breast cancer progression and identify TBX3 targets that can be utilized as therapeutic targets in TBX3-associated breast cancer.鈥� ~ https://nusselab.stanford.edu/people/megan-agajanian/ \nFlyer [pdf] URL:/pharm/event/dr-megan-agajanian-of-stanford-presents/ LOCATION:1131 Bioinformatics\, 130 Mason Farm Rd\, Chapel Hill\, North Carolina\, 27514\, United States CATEGORIES:Pharmacology Seminars ATTACH;FMTTYPE=image/jpeg:/pharm/wp-content/uploads/sites/930/2025/01/megan-agajanian-250.jpg ORGANIZER;CN="Mimi Baltz":MAILTO:my.le@unc.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20250328T110000 DTEND;TZID=America/New_York:20250328T120000 DTSTAMP:20250530T103430 CREATED:20250327T154510Z LAST-MODIFIED:20250327T154510Z UID:10001005-1743159600-1743163200@www.med.unc.edu SUMMARY:Student Research Seminars with Scott Bang\, Amy Aponte and Ryan Robb DESCRIPTION:Scott Bang\, Morris Lab\nAmy Aponte\, Emanuele Lab\nRyan Robb\, Bryant Lab \nHosted by Emma Armstrong\, Morris Lab \nLocation: 4007 GMB \nPizza at 12:00 PM\, following seminar for attendees \nFlyer [pdf] URL:/pharm/event/student-research-seminars-with-scott-bang-amy-aponte-and-ryan-robb/ LOCATION:4007 Genetic Medicine Building\, 120 Mason Farm Rd\, Chapel Hill\, North Carolina\, 27514\, United States CATEGORIES:Student Research Seminars ATTACH;FMTTYPE=image/jpeg:/pharm/wp-content/uploads/sites/930/2025/03/2025_03_28_student_seminar_flyer_Bang_Aponte_Robb.jpg ORGANIZER;CN="April Villaneuva":MAILTO:april_villanueva@med.unc.edu END:VEVENT END:VCALENDAR