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X-WR-CALDESC:Events for Pharmacology
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DTSTART;TZID=America/New_York:20251007T160000
DTEND;TZID=America/New_York:20251007T170000
DTSTAMP:20250428T122626
CREATED:20250106T212053Z
LAST-MODIFIED:20250106T212346Z
UID:10000977-1759852800-1759856400@www.med.unc.edu
SUMMARY:Dr. Sara Buhrlage of the Dana-Farber Cancer Institute presents
DESCRIPTION:Sara Buhrlage\, PhD\nAssociate Professor\nDepartment of Biological Chemistry and Molecular Pharmacology\nHarvard University Medical School and the\nDana-Farber Cancer Institute \nSeminar Title: “TBD” \nPlease join us and show support for our seminar speakers!\n(For those unable to attend\, a zoom link is available upon request to Mimi Baltz.) \nHosts: Mike Emanuele and Nick Brown \nFrom the Buhrlage Lab website: “Our mission is to revolutionize our ability to interrogate deubiquitinase (DUB) biology\, validate DUBs as therapeutic targets\, and develop small molecule-based ligands suitable for clinical development. To accomplish this\, we have established an integrated DUB-centric platform comprised of DUB-targeted libraries with novel scaffolds and chemotypes and a suite of established and novel biochemical and chemoproteomic assays to profile compound activity and selectivity\, as well as expertise in DUB medicinal chemistry\, structural biology\, computational chemistry\, and functional annotation.” ~ https://buhrlagelab.dana-farber.org/
URL:/pharm/event/dr-sara-buhrlage-of-the-dana-farber-cancer-institute-presents/
LOCATION:1131 Bioinformatics\, 130 Mason Farm Rd\, Chapel Hill\, North Carolina\, 27514\, United States
CATEGORIES:Pharmacology Seminars
ATTACH;FMTTYPE=image/jpeg:/pharm/wp-content/uploads/sites/930/2025/01/7884248-Sara-Buhrlage-250.jpg
ORGANIZER;CN="Mimi Baltz":MAILTO:my.le@unc.edu
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DTSTART;TZID=America/New_York:20251014T160000
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UID:10001013-1760457600-1760461200@www.med.unc.edu
SUMMARY:Dr. Marta Filizola
DESCRIPTION:Marta Filizola\, PhD\nProfessor of Pharmacological Sciences and Neuroscience\nDean of the Graduate School of Biomedical Sciences\nIcahn School of Medicine at Mount Sinai\n\nSeminar title: TBD\n\nThis seminar will be in 1131 Bioinformatics\n\nPlease join us and show support for our seminar speakers!\n\n(For those unable to attend\, a zoom link is available upon request to Mimi Baltz.) \nHost: Yinglong Miao \n\n  \nFrom the Filizola website: Our research program aims to obtain rigorous mechanistic insights into the structure\, dynamics\, and function of important classes of membrane proteins and prominent drug targets\, including G protein-coupled receptors (GPCRs)\, transporters\, channels\, and beta3 integrins. Understanding the molecular mechanisms underlying the complex biological functions of these proteins has direct translational relevance because it informs the rational discovery of potentially improved therapeutic agents. To this end\, we use several computational structural biology tools and rational drug design approaches\, ranging from molecular modeling\, bioinformatics\, cheminformatics\, molecular dynamics simulations\, metadynamics\, free-energy perturbations\, artificial intelligence/machine learning\, etc. \nThe strength of our research relies on the integration of state-of-the-art computational methodologies with collaborative experimental approaches to provide valuable mechanistic interpretations at the molecular level of the ligand-induced transmission of the signal to the inner side of the cell membrane. While our research is driven by the exploration and improvement of computational methods to characterize generalizable mechanisms of molecular recognition and signal transduction\, we are excited by the contributions that our computational and modeling efforts make to the experimental field through the generation of new testable hypotheses to support the discovery of improved therapies. (~ https://filizolalab.org) \n 
URL:/pharm/event/dr-marta-filizola/
LOCATION:1131 Bioinformatics\, 130 Mason Farm Rd\, Chapel Hill\, North Carolina\, 27514\, United States
CATEGORIES:Pharmacology Seminars
ATTACH;FMTTYPE=image/jpeg:/pharm/wp-content/uploads/sites/930/2025/04/marta-filizola-250.jpg
ORGANIZER;CN="Mimi Baltz":MAILTO:my.le@unc.edu
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