Dr. Shaun Olsen of the University of Texas San Antonio presents
September 30 @ 4:00 pm - 5:00 pm
Shaun Olsen, PhD
Professor
Department of Biochemistry & Structural Biology
University of Texas, San Antonio
Seminar title:聽TBD
This seminar will be in 1131 Bioinformatics
Please join us and show support for our seminar speakers!
(For those unable to attend, a zoom link is available upon request to聽Mimi Baltz.)
Host: Rob Nicholas
The research in the Olsen laboratory focuses on mechanisms of molecular recognition in protein-protein interactions and on the structural enzymology of proteins essential for cellular function. The majority of his efforts are focused on understanding how enzymes in the ubiquitin (Ub) conjugation cascade (E1, E2, and E3) function together to conjugate Ub to cellular proteins. Post-translational modification of proteins by Ub is a means of regulating fundamental cellular processes including cell cycle control, DNA repair, signal transduction, and immunity. The importance of understanding how the Ub system works is underscored by the fact that dysregulation of Ub signaling is implicated in a number of human disorders and that the pathway is a validated target for therapeutic intervention in cancer. He employs a multidisciplinary approach that includes X-ray crystallography, single particle cryo-EM, enzymology, and a variety of biochemical and biophysical techniques.