黑料网

Skip to main content

Bryan Roth, MD, PhD

Michael Hooker Distinguished Professor, Pharmacology Director, NIMH Psychoactive Drug Screening Program, Eshelman School of Pharmacy Fellow of the American Academy of Arts and Sciences Member of the National Academy of Medicine of the National Academy of Sciences Member, Lineberger Comprehensive Cancer Center

Research Interests

  • GPCR Structure and Function
  • Synthetic Neurobiology
  • Drug Discovery

Research Synopsis

GPCR structure and function

G-protein coupled receptors (GPCRs) represent one of the most evolutionarily diverse superfamilies of the human genome. My lab studies all aspects of GPCR structure and function ranging from the atomic-level analysis of ligand-receptor interactions to in vivo studies. Currently we are focused on members of the serotonin () and听听families and their accessory proteins.

Synthetic neurobiology

We invented the chemogenetic technology dubbed: DREADD () which is currently used by 100鈥檚 of labs around the world (see听 for recent paper).

Drug Discovery

We are actively engaged in drug discovery efforts via the shared resources of the National Institute of Mental Health’s Psychoactive Drug Screening Program. Our goals are to discover and develop novel small molecule probes for in vitro and in vivo validation of molecular targets for therapeutic drug discovery. We have particular strengths with GPCR and ion-channels and have expanded our capabilities to enable screening of the entire GPCR-ome in massively parallel screening campaigns (see听; Huang et al, Nature in press and听听for recent papers).

Recent Publications

All Publications

Bryan Roth, MD, PhD