黑料网

EMAIL: sramos@med.unc.edu

PERSONAL WEBSITE:

PUBLICATIONS:

We are interested in interconnecting medical standpoints with basic research concepts to ask relevant scientific questions. As an MD/PhD, I have the training and experience to approach these questions from both clinical and basic science perspectives. I acquired clinical experience treating patients as a clinical immunologist in Brazil and in the US as a clinical embryologist at 黑料网. My PhD training was in Immunology. During my post-doctoral work at NIEHS-NIH in Dr. Perry Blackshear lab, using genetically-engineered mouse models, my findings led me to the intriguing field of reproductive biology and female infertility. We brought this new research endeavor implicating the role of Zinc Finger Protein 36 Like 2 (ZFP36L2, 鈥淟2鈥�) an RNA-binding protein in mouse infertility to set up an independent research program at 黑料网-CH in the Department of Obstetrics and Gynecology, and run the clinical IVF lab. Then, most of our time was devoted to clinical activities and in acquiring knowledge and advanced skills on human embryology. In 2010, by passing the ABB examination, I became a fully certified Embryology Lab Director. In 2012, I obtained an NICHD K08 award, mentored and co-mentored by Drs. William Marzluff and Kathleen Caron, respectively. During my K08 award, I published seven papers, including some in high impact journals such as Nature, PNAS and NAR. On the summer of 2014 I joined the Department of Biochemistry and Biophysics with the goal of expanding the role of ZFP36L2 from ovarian infertility (ovulation and oocyte maturation defects) to novel biological and biochemical connections. Our most recent findings confirm that ZFP36L2 is essential for life, due to its role in hematopoiesis differentiation during mouse post-natal period. Our work has been scientifically recognized as exemplified by receiving a Carl Storm Underrepresented Minority (CSURM) Fellowship to the Gordon Research Conference on Post-Transcriptional Gene Regulation in 2022, invitation to chair a section and give a talk at the FASEB RNA Decay meeting in 2022, an RNA travel award in 2019 from the RNA Society, NSF Talk Award at the FASEB RNA Decay meeting in 2018. As a NIH new investigator, to successfully accomplish the goals of our research proposal, we count on a multidisciplinary team comprising accomplished 黑料网 colleagues from departments of Biology and Bioinfromatics, Chemistry, Biochemistry and Pharmacology. We established collaborations with Drs. Alain Laederach, Kevin Weeks and Jean Cook from 黑料网 and with Dr. Raymond Cho from UCSF. I am delighted to lead our research team and extend our collaborations, with the goal of defining the molecular functions of ZFP36 L2-mediated mRNA turnover in physiologycal conditions and human diseases.