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Food allergy, Chronic Idiopathic Urticaria (CIU) and Angioedema and Medical Education,

My research interests have ranged from basic laboratory studies of the interactions between cells/cellular organelles with the coagulation system, to large case-control and prospective cohort studies in bleeding and clotting disorders. For many years, my laboratory has maintained an active interest in the mechanisms underlying the excessive activation of coagulation...

Airway Mucin and Mucus Biochemistry and Proteomics

Bleeding and clotting disorders, and聽Hereditary Hemorrhagic Telangiectasia

Emotional behavior is regulated by a host of chemicals, including neurotransmitters and neuromodulators, acting on specific circuits within the brain.聽 There is strong evidence for the existence of both endogenous stress and anti-stress systems.聽 Chronic exposure to drugs of abuse and stress are hypothesized to modulate the relative balance of...

I leverage novel mouse models toward the elucidation of pathophysiological mechanisms underlying neurodevelopmental disorders, with the ultimate goal of developing efficacious gene therapies. Currently, I am preclinically testing a gene transfer therapy for Angelman syndrome and exploring opportunities to treat Dup15q syndrome with UBE3A-targeting antisense oligonucleotides.

Dr. Joyner is a pediatric intensivist whose research specializes in simulation training and innovative forms of medical education. He focuses on developing novel simulation strategies utilizing current high-fidelity technology to explore its use in novel situations as well as exploring how to better implement this technology given time and resource...

Dr. Jennette鈥檚 more basic research (funded by NIH NIDDK) focuses on the pathogenesis of glomerulonephritis, vasculitis and granulomatosis caused by anti-neutrophil cytoplasmic autoantibodies (ANCA) using in vitro assays, animal models, and human specimens. In collaboration with Dr. Hong Xiao and Dr. Peiqi Hu, he utilizes animal models of ANCA disease...

Dr. Jaspers is a pediatric microbiologist and immunologist with expertise on exposure to environmental oxidants and its impact on human immune responses. She has established several human in vitro and clinical in vivo models to determine the adverse health effects induced by pollutant exposures. Dr. Jaspers collaborates extensively with investigators...

Clinical Interests Myasthenia gravis, neuromuscular disorders, clinical neurophysiology (neurography [NCS], electromyography [EMG, quantitative EMG, single fiber EMG]), neuromuscular education of trainees Clinical Research Interests Diagnosis and treatment of myasthenia gravis Basic Research Interests Immunomodulatory role of lymphocytes in myasthenia gravis

Research in our laboratory spans the division between clinical and basic science investigations of non-viral sexually transmitted pathogens including Trichomonas vaginalis, Neisseria gonorrhoeae, Chlamydia trachomatis and Mycoplasma genitalium. As part of the NC Sexually Transmitted Infections and Southeastern Sexually Transmitted Infections Cooperative Research Center, we are developing a genotyping system...

My research interest focuses on the mechanisms of cancer-associated thrombosis and bleeding. My primary interest is mechanisms of pancreatic cancer-associated venous thrombosis because pancreatic cancer has one of the highest rates of venous thrombosis. I have found that tumor-derived tissue factor positive extracellular vesicles, neutrophils and neutrophil extracellular traps, and...