| EMAIL: | PUBLICATIONS: |
Dr. Jennette鈥檚 more basic research (funded by NIH NIDDK) focuses on the pathogenesis of glomerulonephritis, vasculitis and granulomatosis caused by anti-neutrophil cytoplasmic autoantibodies (ANCA) using in vitro assays, animal models, and human specimens. In collaboration with Dr. Hong Xiao and Dr. Peiqi Hu, he utilizes animal models of ANCA disease discovered in their laboratory that are induced by mouse anti-myeloperoxidase (anti-MPO) antibodies. These models allow elucidation of pathogenic pathways responsible for the induction of ANCA glomerulonephritis, microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA) and eosinophilic granulomatosis with polyangiitis (EGPA); and have resulted in the discovery of important targets for novel therapy for ANCA disease.
Dr. Jennette鈥檚 clinical and clinicopathologic studies of kidney disease have focused on a wide variety of glomerular diseases including minimal change disease, focal segmental glomerulosclerosis, C1q nephropathy, membranous nephropathy, diabetic glomerulosclerosis, IgA nephropathy, lupus nephritis, anti-GBM glomerulonephritis, and ANCA-glomerulonephritis. His clinical research and scholarship on systemic vasculitis includes leadership in formulating the Chapel Hill Consensus Conference Nomenclature of Systemic Vasculitides, which is used worldwide as a guideline for classification and diagnosis of systemic vasculitis.
| AFFILIATIONS: | CATEGORIES: |