{"id":7315,"date":"2025-01-02T10:24:42","date_gmt":"2025-01-02T15:24:42","guid":{"rendered":"https:\/\/www.med.unc.edu\/neuroscience\/?p=7315"},"modified":"2025-01-02T10:25:10","modified_gmt":"2025-01-02T15:25:10","slug":"structure-guided-design-of-a-peripherally-restricted-chemogenetic-system","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/neuroscience\/structure-guided-design-of-a-peripherally-restricted-chemogenetic-system\/","title":{"rendered":"Structure-guided design of a peripherally restricted chemogenetic system"},"content":{"rendered":"

Kang et\u00a0al. present HCAD, a peripherally restricted DREADD based on HCA2, with a chemical actuator that avoids crossing the blood-brain barrier and selectively reduces pain in mice. This system will enable the study of peripheral physiology without affecting the central nervous system.<\/p>\n

Publication found here<\/a>.<\/p>\n

\"\"<\/p>\n","protected":false},"excerpt":{"rendered":"

Kang et\u00a0al. present HCAD, a peripherally restricted DREADD based on HCA2, with a chemical actuator that avoids crossing the blood-brain barrier and selectively reduces pain in mice. This system will enable the study of peripheral physiology without affecting the central nervous system. Publication found here.<\/p>\n","protected":false},"author":7858,"featured_media":7316,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-7315","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"yoast_head":"\nStructure-guided design of a peripherally restricted chemogenetic system | 黑料网 Neuroscience Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/neuroscience\/structure-guided-design-of-a-peripherally-restricted-chemogenetic-system\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Structure-guided design of a peripherally restricted chemogenetic system | 黑料网 Neuroscience Center\" \/>\n<meta property=\"og:description\" content=\"Kang et\u00a0al. present HCAD, a peripherally restricted DREADD based on HCA2, with a chemical actuator that avoids crossing the blood-brain barrier and selectively reduces pain in mice. This system will enable the study of peripheral physiology without affecting the central nervous system. 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