Amanda E. Nelson, MD, MSCR, RhMSUS, professor of medicine in the Division of Rheumatology, Allergy and Immunology, and other Thurston Arthritis Research Center researchers coauthored a study entitled, “Translational genomics of osteoarthritis in 1,962,069 individuals” in Nature. Their study represents the largest genome-wide association study conducted to date on osteoarthritis (OA), confidently linked 700 genes to the condition. Their findings reveal promising new directions for drug development and therapeutic intervention.
A key contribution from the 黑料网 team was data from the long-standing Johnston County Osteoarthritis Project (JoCoOA), which played a pivotal role in enriching the study鈥檚 robust dataset of nearly 2 million individuals. This global collaboration led to the identification of more than 900 genetic associations with OA, over 500 of which are newly discovered.