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Brian Button, PhD

Professor

Specialty Areas:

Mucus biophysical properties, role of the Pericilliary Layer (PCL), and mechanisms of mucociliary clearance in the airways

Selected Bibliography:

  1. Dunne OM, Martin SL, Sergeant GP, McAuley DF, O’Kane CM, Button B, McGarvey LP, Lundy FT. . Respir Res. 2024 Apr 27;25(1):188. doi: 10.1186/s12931-024-02807-0. PMID: 38678280; PMCID: PMC11056070.
  2. Donoghue LJ, Markovetz MR, Morrison CB, Chen G, McFadden KM, Sadritabrizi T, Gutay MI, Kato T, Rogers TD, Snead JY, Livraghi-Butrico A, Button B, Ehre C, Grubb BR, Hill DB, Kelada SNP. . Am J Physiol Lung Cell Mol Physiol. 2023 Dec 1;325(6):L765-L775. doi: 10.1152/ajplung.00390.2022. PMID: 37847709. PMCID: PMC11068428.
  3. Cao R, Rossdeutcher RB, Zhong Y, Shen Y, Miller DP, Sobiech TA, Wu X, Buitrago LS, Ramcharan K, Gutay MI, Figueira MF, Luthra P, Zurek E, Szyperski T, Button B, Shao Z, Gong B. . Nat Chem. 2023 Nov;15(11):1559-1568. doi: 10.1038/s41557-023-01315-w. PMID: 37814114.
  4. Mikami Y, Grubb BR, Rogers TD, Dang H, Asakura T, Kota P, Gilmore RC, Okuda K, Morton LC, Sun L, Chen G, Wykoff JA, Ehre C, Vilar J, van Heusden C, Livraghi-Butrico A, Gentzsch M, Button B, Stutts MJ, Randell SH, O’Neal WK, Boucher RC. . Sci Transl Med. 2023 Jun 7;15(699):eabo7728. doi: 10.1126/scitranslmed.abo7728. PMID: 37285404. PMCID: PMC10664029.
  5. Hill DB*, Button B*, Rubinstein M, Boucher RC. . Physiol Rev. 2022 Oct 1;102(4):1757-1836. doi: 10.1152/physrev.00004.2021. PMID: 35001665. PMCID: PMC9665957. *Co-first authors.
  6. Biering SB, Sarnik SA, Wang E, Zengel JR, Leist SR, Sch盲fer A, Sathyan V, Hawkins P, Okuda K, Tau C, Jangid AR, Duffy CV, Wei J, Gilmore RC, Alfajaro MM, Strine MS, Nguyenla X, Van Dis E, Catamura C, Yamashiro LH, Belk JA, Begeman A, Stark JC, Shon DJ, Fox DM, Ezzatpour S, Huang E, Olegario N, Rustagi A, Volmer AS, Livraghi-Butrico A, Wehri E, Behringer RR, Cheon DJ, Schaletzky J, Aguilar HC, Puschnik AS,听Button B, Pinsky BA, Blish CA, Baric RS, O’Neal WK, Bertozzi CR, Wilen CB, Boucher RC, Carette JE, Stanley SA, Harris E, Konermann S, Hsu PD.听. Nat Genet.听2022 Aug;54(8):1078-1089. doi: 10.1038/s41588-022-01131-x. PMID: 35879412.听PMCID: PMC9355872.
  7. Figueira MF, Ribeiro CMP,听Button B.听. Curr Opin Pharmacol. 2022 Aug;65:102248. doi: 10.1016/j.coph.2022.102248. PMID: 35689870. PMCID: PMC9891491.
  8. Kato T, Radicioni G, Papanikolas MJ, Stoychev GV, Markovetz MR, Aoki K, Porterfield M, Okuda K, Barbosa Cardenas SM, Gilmore RC, Morrison CB, Ehre C, Burns KA, White KK, Brennan TA, Goodell HP, Thacker H, Loznev HT, Forsberg LJ, Nagase T, Rubinstein M, Randell SH, Tiemeyer M, Hill DB, Kesimer M, O’Neal WK, Ballard ST, Freeman R, Button B, Boucher RC. . Sci Adv. 2022 Apr;8(13):eabm9718. doi: 10.1126/sciadv.abm9718. PMID: 35363522.
  9. Rogers TD, Button B, Kelada SNP, Ostrowski LE, Livraghi-Butrico A, Gutay MI, Esther CR Jr, Grubb BR. . Front Physiol. 2022 Mar 9;13:842592. doi: 10.3389/fphys.2022.842592. PMID: 35356083; PMCID: PMC8959816.
  10. Dahl DK, Whitesell AN, Sharma-Huynh P, Maturavongsadit P, Janusziewicz R, Fox RJ, Loznev HT,听Button B, Schorzman AN, Zamboni W, Ban J, Montgomery SA, Carey ET, Rahima Benhabbour S.听. Int J Pharm. 2022 Jan 25;612:121288. doi: 10.1016/j.ijpharm.2021.121288. PMID: 34800616. PMCID: PMC8753993.
  11. van Heusden C, Grubb BR, Button B, Lazarowski ER. . Life (Basel). 2021 May 11;11(5):430. doi: 10.3390/life11050430. PMID: 34064654; PMCID: PMC8151306.
  12. Bennett WD, Henderson AG, Ceppe A, Zeman KL, Wu J, Gladman C, Fuller F, Gazda S, Button B, Boucher RC, Donaldson SH. . ERJ Open Res. 2020 Aug 11;6(3):00269-2020. doi: 10.1183/23120541.00269-2020. PMID: 32802823. PMCID: PMC7418818.
  13. Danahay HL, Lilley S, Fox R, Charlton H, Sabater J, Button B, McCarthy C, Collingwood SP, Gosling M. . Am J Respir Crit Care Med. 2020 Apr 15;201(8):946-954. doi: 10.1164/rccm.201908-1641OC. PMID: 31898911. PMCID: PMC7159426.
  14. Ramsey KA, Chen ACH, Radicioni G, Lourie R, Martin M, Broomfield A, Sheng YH, Hasnain SZ, Radford-Smith G, Simms LA, Burr L, Thornton DJ, Bowler SD, Livengood S, Ceppe A, Knowles MR, Noone PG, Donaldson SH, Hill DB, Ehre C, Button B, Alexis NE, Kesimer M, Boucher RC, McGuckin MA. . Am J Respir Crit Care Med. 2020 Mar 15;201(6):661-670. doi: 10.1164/rccm.201906-1219OC. PMID: 31765597. PMCID: PMC7068838.
  15. van Heusden C, Button B, Anderson WH, Ceppe A, Morton LC, O’Neal WK, Dang H, Alexis NE, Donaldson SH, Stephan H, Boucher RC, Lazarowski ER. . Am J Physiol Lung Cell Mol Physiol. 2020 Feb 1;318(2):L356-L365. doi: 10.1152/ajplung.00449.2019. PMID: 31800264. PMCID: PMC7052677.
  16. Brinks V, Lipinska K, de Jager M, Beumer W, Button B, Livraghi-Butrico A, Henig N, Matthee B. . J Aerosol Med Pulm Drug Deliv. 2019 Oct;32(5):303-316. doi: 10.1089/jamp.2018.1502. PMID: 31120356. PMCID: PMC6781260.
  17. Chen G, Sun L, Kato T, Okuda K, Martino MB, Abzhanova A, Lin JM, Gilmore RC, Batson BD, Volmer AS, Dang H, Deng Y, Randell SH, Button B, Livraghi-Butrico A, Kesimer M, Ribeiro CMP, O鈥橬eal WK, Boucher RC. . J Clin Invest. 2019 Oct 1;129(10):4433-4450. doi: 10.1172/JCI125669. PMID: 31524632. PMCID: PMC6763234.
  18. Goodell HP, Shenoy SK, Shenkute NT, Lackey E, Dennis RG, Button B. . Bio Protoc. 2019 Jul 5;9(13). doi: 10.21769/BioProtoc.3287. PMID: 31687423. PMCID: PMC6827558.
  19. Henderson AG, Anderson WH, Ceppe A, Coakley RD, Button B, Alexis NE, Peden DB, Lazarowski ER, Davis CW, Fuller F, Almond M, Qaqish B, Kesimer M, Boucher RC. . COPD. 2018 Dec;15(6):572-580. doi: 10.1080/15412555.2019.1566892. PMID: 30712400. PMCID: PMC6428611.
  20. Hill DB, Long RF, Kissner WJ, Atieh E, Garbarine IC, Markovetz MR, Fontana NC, Christy M, Habibpour M, Tarran R, Forest MG, Boucher RC, Button B. Pathological Mucus and Impaired Mucus Clearance in Cystic Fibrosis Patients Results from Increased Concentration, not altered pH. Eur Respir J. 2018 Dec 6;52(6). doi: 10.1183/13993003.01297-2018. PMID: 30361244.听PMCID:听PMC6446239.
  21. Button B, Goodell HP, Atieh E, Chen YC, Williams R, Shenoy S, Lackey E, Shenkute N, Cai L, Dennis R, Boucher RC, Rubinstein M. . Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):12501-12506. doi: 10.1073/pnas.1811787115. PMID: 30420506.听PMCID:听PMC6298066.
  22. Rogers TD,听Ostrowski LE,听Livraghi-Butrico A,听Button B,听Grubb BR.听.听Sci Rep.听2018 Oct 3;8(1):14744. doi: 10.1038/s41598-018-33053-2.听PMID:听30282981. PMCID:听PMC6170422.
  23. Goralski JL, Wu D, Thelin WR, Boucher RC, Button B. . Eur Respir J. 2018 May 17;51(5). doi: 10.1183/13993003.02652-2017. PMID: 29599187. PMCID: PMC6000726.
  24. Wu D, Boucher RC, Button B, Elston T, Lin CL. . J Theor Biol. 2018 Feb 7;438:34-45. doi: 10.1016/j.jtbi.2017.11.010. PMID: 29154907. PMCID: PMC5764545.
  25. Schultz A, Puvvadi R, Borisov SM, Shaw NC, Klimant I, Berry LJ, Montgomery ST, Nguyen T, Kreda SM, Kicic A, Noble PB, Button B, Stick SM. . Nat Commun. 2017 Nov 10;8(1):1409. doi: 10.1038/s41467-017-00532-5. PMID: 29123085. PMCID: PMC5680186.
  26. Esther CR Jr, Hill DB, Button B, Shi S, Jania CM, Duncan EA, Doerschuk CM, Chen G, Ranganathan S, Stick SM, Boucher RC. Am J Physiol Lung Cell Mol Physiol. 2017 Mar 1;312(3):L398-404. doi: 10.1152/ajplung.00398.2016. PMID: 28062483. PMCID: PMC5374301.
  27. Anderson WH, Coakley RD, Button B, Henderson AG, Zeman KL, Alexis NE, Peden DB, Lazarowski ER, Davis CW, Bailey S, Fuller F, Almond M, Qaqish B, Bordonali E, Rubinstein M, Bennett WD, Kesimer M, Boucher RC. Am J Respir Crit Care Med. 2015 Jul 15;192(2):182-90. doi: 10.1164/rccm.201412-2230OC. PMID: 25909230; PMCID: PMC4532825.
  28. Chhetri RK, Blackmon RL, Wu WC, Hill DB, Button B, Casbas-Hernandez P, Troester MA, Tracy JB, Oldenburg AL. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):E4289-97. doi: 10.1073/pnas.1409321111. PMID: 25267619; PMCID: PMC4205670.
  29. Henderson AG, Ehre C, Button B, Abdullah LH, Cai LH, Leigh MW, DeMaria GC, Matsui H, Donaldson SH, Davis CW, Sheehan JK, Boucher RC, Kesimer M. J Clin Invest. 2014 Jul;124(7):3047-60. doi: 10.1172/JCI73469. PMID: 24892808; PMCID: PMC4072023.
  30. Button B, Okada SF, Frederick CB, Thelin WR, Boucher RC. Sci Signal. 2013 Jun 11;6(279):ra46. doi: 10.1126/scisignal.2003755. PMID: 23757023; PMCID: PMC3791865.
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Headshot of Brian Button