{"id":2843,"date":"2016-10-24T19:18:03","date_gmt":"2016-10-24T23:18:03","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/directory\/a-gregory-matera-phd\/"},"modified":"2025-04-24T14:57:35","modified_gmt":"2025-04-24T18:57:35","slug":"a-gregory-matera-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/genetics\/directory\/a-gregory-matera-phd\/","title":{"rendered":"A. Gregory Matera, PhD"},"content":{"rendered":"<p><!-- description --><\/p>\n<h2>Research Interests<\/h2>\n<p><strong class=\"keywords\">Keywords: Genetics and Cell Biology of RNP assembly and transport, animal models of a human disease \u2013 Spinal Muscular Atrophy, developmental regulation of post-transcriptional histone modifications<\/strong><\/p>\n<p>We use three different model systems (fruitfly, mouse and human) to study the molecular, cellular and developmental biology of small nuclear ribonucleoproteins (snRNPs). Why are snRNPs so interesting?<\/p>\n<ul>\n<li>Without snRNPs, pre-mRNA splicing (and thus eukaryotic life) would not be possible.<\/li>\n<li>The biogenesis of snRNPs is a paradigm for assembly of other factors, such as micro RNPs.<\/li>\n<li>A reduced capacity for snRNP biogenesis is associated with a neurogenetic disorder, called Spinal Muscular Atrophy (SMA).<\/li>\n<\/ul>\n<p>Small nuclear ribonucleoproteins (snRNPs; pronounced \u2018snurps\u2019) are required for pre-messenger RNA splicing and are thus essential components of all eukaryotic cells. Whereas the basic mechanics of splicing are fairly well-understood, the biogenesis of snRNPs is relatively unclear. The long-term goal of our laboratory is to understand the molecular mechanisms that govern the assembly and subcellular localization of small RNPs. In short, we seek to uncover the process by which snRNPs are packaged, transported and delivered to their nuclear sites of action. Curiously, the initial phases of snRNP biogenesis actually begin in the cytoplasm, following nuclear export of the pre-snRNA transcript. Assembly into stable RNP particles is mediated by the Survival Motor Neurons (SMN) protein complex. Subsequently, these small RNPs are imported back into the nucleus. Defects in the assembly of Sm-class small RNPs are associated with a neuromuscular disorder called Spinal Muscular Atrophy (SMA). Patients with SMA typically die in childhood. Although snRNP biogenesis is compromised in patient-derived cells, the underlying cause of the SMA phenotype is not understood. Thus a detailed understanding of snRNP metabolism is essential not only to the study of RNA processing, but will also be important in developing treatments for neuromuscular disease. To gain insight into the biogenesis of snRNPs and its role in the pathogenesis of SMA, we have developed models in <em>Drosophila<\/em> and mammalian systems to study small RNP trafficking and assembly.<\/p>\n<h2>A. Greg Matera in 黑料网 Genetics News<\/h2>\n            <div class=\"wc-cards\"><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-february-2nd-march-1st-2025\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"黑料网 Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">March 3, 2025<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for February 2nd &#8211; March 1st, 2025<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 18 papers during February 2nd - March 1st 2025.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for February 2nd &#8211; March 1st, 2025\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-november-10th-23rd-2024\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"黑料网 Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">December 3, 2024<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for November 10th &#8211; 23rd, 2024<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 19 papers during November 10th - 23rd, 2024.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for November 10th &#8211; 23rd, 2024\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-october-27th-november-9th-2024\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"黑料网 Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">November 11, 2024<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for October 27th &#8211; November 9th, 2024<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 8 papers during October 27th - November 9th, 2024.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for October 27th &#8211; November 9th, 2024\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-october-13th-26th-2024\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"黑料网 Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">October 28, 2024<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for October 13th &#8211; 26th, 2024<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 13 papers during October 13th - 26th, 2024.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for October 13th &#8211; 26th, 2024\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-july-21st-august-3rd-2024\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"黑料网 Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">August 5, 2024<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for July 21st &#8211; August 3rd, 2024<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 13 papers during July 21st - August 3rd 2024.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for July 21st &#8211; August 3rd, 2024\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-april-14th-27th-2024\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"黑料网 Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">April 29, 2024<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for April 14th &#8211; 27th, 2024<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 12 papers during April 14th - 27th 2024.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for April 14th &#8211; 27th, 2024\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-february-18th-march-2nd-2024\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"黑料网 Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">March 3, 2024<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for February 18th &#8211; March 2nd, 2024<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 11 papers during February 18th - March 2nd 2024.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for February 18th &#8211; March 2nd, 2024\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-october-8th-21st-2023\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"黑料网 Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">October 23, 2023<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for October 8th &#8211; 21st, 2023<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 9 papers during October 8th - 21st 2023.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for October 8th &#8211; 21st, 2023\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-june-4th-17th-2023\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"黑料网 Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">June 19, 2023<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for June 4th &#8211; 17th, 2023<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 10 papers during June 4th - 17th, 2023.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for June 4th &#8211; 17th, 2023\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-may-21st-june-3rd-2023\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"黑料网 Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">June 4, 2023<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for May 21st \u2013 June 3rd, 2023<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 15 papers during May 21st \u2013 June 3rd, 2023.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for May 21st \u2013 June 3rd, 2023\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article>            <\/div>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research Interests Keywords: Genetics and Cell Biology of RNP assembly and transport, animal models of a human disease \u2013 Spinal Muscular Atrophy, developmental regulation of post-transcriptional histone modifications We use three different model systems (fruitfly, mouse and human) to study the molecular, cellular and developmental biology of small nuclear ribonucleoproteins (snRNPs). Why are snRNPs so &hellip; <a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-may-21st-june-3rd-2023\/\" aria-label=\"Read more about Department of Genetics Publications for May 21st \u2013 June 3rd, 2023\">Read more<\/a><\/p>\n","protected":false},"featured_media":8484,"template":"","meta":{"_acf_changed":false,"_links_to":"","_links_to_target":""},"class_list":["post-2843","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A. Gregory Matera, PhD | Department of Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/genetics\/directory\/a-gregory-matera-phd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A. Gregory Matera, PhD | Department of Genetics\" \/>\n<meta property=\"og:description\" content=\"Research Interests Keywords: Genetics and Cell Biology of RNP assembly and transport, animal models of a human disease \u2013 Spinal Muscular Atrophy, developmental regulation of post-transcriptional histone modifications We use three different model systems (fruitfly, mouse and human) to study the molecular, cellular and developmental biology of small nuclear ribonucleoproteins (snRNPs). 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