Yun Li, PhD (Professor, Genetics and Biostatistics) is a co-corresponding author together with Quan Sun (Biostatistics doctoral candidate) on a published in the American Journal of Human Genetics, titled 鈥淥pportunities and challenges of local ancestry in genetic association analysis鈥�.
Additional authors from the Department of Genetics include Drs. Andrea Horimoto, Dr. Laura Raffield, and Dr. Karen Mohlke.聽 The review summarizes methods for聽local ancestry inference and illustrates how local ancestry can be utilized in various analyses, including admixture mapping, association testing, and polygenic risk score construction. In addition, current challenges in research involving local ancestry, both in terms of the inference itself and its role in genetic association studies are discussed. Finally, future study directions and methodology development opportunities to help more effectively incorporate local ancestry in genetic analyses are proposed.