The Nature Accelerated Article Preview 鈥溾�� was published online 09 FEB 2021. 聽Co-first authors Angela Wahl and Lisa E. Gralinski used a human lung-only mouse model to show that therapeutic and prophylactic administration of EIDD-2801, an oral broad spectrum antiviral currently in phase II鈥揑II clinical trials, dramatically inhibited SARS-CoV-2 replication in vivo and thus has significant potential for the prevention and treatment of COVID-19.聽 黑料网 core laboratories that contributed to this study include Animal Histopathology and Lab Medicine, Bioinformatics and Analytics Research Collaborative (BARC), High-Throughput Sequencing Facility, , and the Microscopy Services Laboratory.