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DTSTART;TZID=America/New_York:20250509T100000
DTEND;TZID=America/New_York:20250509T110000
DTSTAMP:20250428T173601
CREATED:20241205T173425Z
LAST-MODIFIED:20250417T142949Z
UID:10000445-1746784800-1746788400@www.med.unc.edu
SUMMARY:Research in Progress | Tim Daugird (Purvis lab)
DESCRIPTION:In-person | Mary Ellen Jones 3116 \nVirtual |  ZOOM LINK  (passcode RESEARCH) \n 
URL:/compmed/event/research-in-progress-tim-daugird-purvis-lab/
LOCATION:Mary Ellen Jones 3116\, 116 Manning Drive\, Chapel Hill\, NC\, 27599\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250515T140000
DTEND;TZID=America/New_York:20250515T150000
DTSTAMP:20250428T173601
CREATED:20250109T190135Z
LAST-MODIFIED:20250109T203657Z
UID:10000447-1747317600-1747321200@www.med.unc.edu
SUMMARY:Seminar with Olga Anczukȯw\, Ph.D.
DESCRIPTION:  \nIn-person only \n  \n \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \nAbout the speaker:  \nDr. Olga Anczuków\, PhD\, Associate Professor at The Jackson Laboratory for Genomic Medicine\, Farmington\, CT\, is an investigator with expertise in RNA and cancer biology. She is a Research Program Co-Leader at the NCI-designated Jackson Laboratory Cancer Center. She completed her PhD at University Claude Bernard Lyon 1 in France\, and her postdoctoral training at Cold Spring Harbor laboratory\, NY\, USA. \nThe goals of her research program (www.anczukowlab.com) are to understand how misregulation of alternative RNA splicing\, including alterations driven by aging\, contributes to cancer\, and to develop novel therapeutic strategies to target splicing regulators and their targets. \nHer laboratory uses patient-derived organoids\, mouse models\, and RNA-sequencing to identify splicing alterations that contribute to tumor initiation\, metastasis\, and drug resistance. She identified splicing factors and their targets that promote tumor initiation and/or invasion and metastasis in in vivo and in vitro models of breast cancer. Using short- and long-read RNA-sequencing\, her work further defined the splicing landscape of human primary tumors and discovered novel tumor-specific full-length isoforms associated with prognosis in breast cancer\, as well as other tumors types. In particular\, her work revealed a pan-cancer splicing signature of MYC activity and nominated novel targets for MYC-driven tumors. Finally\, her lab is leveraging RNA-based therapeutics to study the function of specific aging and cancer-associated isoforms as well as to design novel drugs for tumors with splicing alterations.  \nShe is the Principal Investigator on four major grants (NCI R01\, NIGMS R01\, NCI R21/R33\, and a Hevolution Foundation Advancing Geroscience Efforts Award) which support her unique program’s integrative research approach\, which connects the fields of RNA biology\, cancer research\, and aging to reveal novel avenues for mechanistic discovery and new personalized cancer therapies. She is a member of the RNA Society and the American Association for Cancer Research\, and member of the AACR Task Force on Aging and Cancer. She co-organized multiple international conferences\, including the FASEB RNA Processing in Cancer Conference: From Bench to Bedside (2023)\, the Forbeck Forum on Therapeutic Targeting of mRNA splicing in Cancer (2023)\, and the JAX Long read sequencing workshop (2024). She serves or has served on NIH study sections and peer review groups in the US and abroad\, in addition to reviewing manuscripts for a range of leading journals. She is also dynamically engaged in the research community\, in the training of the next generation of cancer researchers\, and in science outreach programs. \n  \n  \n  \n  \n 
URL:/compmed/event/seminar-with-olga-anczuk%c8%afw-ph-d/
LOCATION:Bioinformatics Building\, Room 1131\, 130 Mason Farm Rd\, Chapel Hill\, NC\, 27514\, United States
CATEGORIES:Seminar
ATTACH;FMTTYPE=image/jpeg:/compmed/wp-content/uploads/sites/852/2025/01/Olga_Anczukow_portrait_headshot_rectangle.jpg
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250516T100000
DTEND;TZID=America/New_York:20250516T110000
DTSTAMP:20250428T173601
CREATED:20241205T173519Z
LAST-MODIFIED:20241205T173519Z
UID:10000446-1747389600-1747393200@www.med.unc.edu
SUMMARY:Research in Progress | Kalika Kamat (Ferris/Heise Labs)
DESCRIPTION:
URL:/compmed/event/research-in-progress-kalika-kamat-ferris-heise-labs/
LOCATION:Mary Ellen Jones 3116\, 116 Manning Drive\, Chapel Hill\, NC\, 27599\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250604T153000
DTEND;TZID=America/New_York:20250604T163000
DTSTAMP:20250428T173601
CREATED:20250415T184019Z
LAST-MODIFIED:20250415T184019Z
UID:10000451-1749051000-1749054600@www.med.unc.edu
SUMMARY:PHCO 5th Annual Dr. Curtis Harper Distinguished Lectureship
DESCRIPTION:2025 Curtis Harper Flyer
URL:/compmed/event/phco-5th-annual-dr-curtis-harper-distinguished-lectureship/
LOCATION:MBRB 2204 Medical Biomolecular Research Building\, 111 Mason Farm Road\, Chapel Hill\, NC\, 27599\, United States
ATTACH;FMTTYPE=application/pdf:/compmed/wp-content/uploads/sites/852/2025/04/2025-Curtis-Harper-Flyer-1-1.pdf
ORGANIZER;CN="Jessica Tran":MAILTO:Jessica_Tran@med.unc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250918T140000
DTEND;TZID=America/New_York:20250918T150000
DTSTAMP:20250428T173601
CREATED:20250114T203048Z
LAST-MODIFIED:20250114T205831Z
UID:10000448-1758204000-1758207600@www.med.unc.edu
SUMMARY:Seminar with Adam MacLean\, PhD
DESCRIPTION:In-person only \n  \nTalk Title: Gene regulatory network dynamics and the fate of single cells \nAbstract: \nCells make decisions to enable multicellular life. Cell fate decision-making underlies development and homeostasis\, and goes awry as we age. Despite great promise\, we have yet to harness the high-resolution information on cell states and fates that single-cell genomics data offer to understand cell fate decisions in development and aging. Nor do we know how these fate decisions are controlled by gene regulatory networks. I will describe our recent work constructing models of cell fate decisions and their control by gene regulatory networks using single-cell genomics. In application to the human lifetime\, we have discovered how early-life events — mutational\, transcriptional\, and epigenetic — shape and change stem cell function as we age in a manner that could be harnessed to ameliorate diseases of aging. \n  \nAbout the speaker:  \nAdam MacLean develops theory to understand cell fate decision-making in stem cells and cancer. He has developed models of cell-cell communication\, and the gene regulatory networks that control cell fate decisions via single-cell multi-omics data analysis and statistical inference. He is an Assistant Professor in the Department of Quantitative and Computational Biology\, at the University of Southern California. He studied mathematical physics (BSc) at the University of Edinburgh and completed a PhD in systems biology from Imperial College London. He worked as a postdoc at the University of Oxford and the University of California Irvine\, before joining USC in 2019. Recent awards for his work include an NSF CAREER award (2022) and an NIH R35 MIRA award (2022). \n 
URL:/compmed/event/seminar-with-adam-maclean-phd/
LOCATION:Bioinformatics Building\, Room 1131\, 130 Mason Farm Rd\, Chapel Hill\, NC\, 27514\, United States
CATEGORIES:Seminar
ATTACH;FMTTYPE=image/jpeg:/compmed/wp-content/uploads/sites/852/2025/01/macleana.jpg
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