Research Summary
Dr. Magness’ research focuses on the genetic mechanisms that regulate intestinal and colonic stem cell maintenance and differentiation, with applications in normal physiology, injury response, and diseases such as inflammatory bowel disease (IBD) and cancer. His work explores how SOX transcription factors, mitogens, morphogens, and the extracellular matrix influence cell fate decisions and stem cell self-renewal. His team has discovered significant heterogeneity within seemingly homogenous cell populations, driving the development of advanced single-cell genomics and imaging techniques, supported by a Core facility that he established. Dr. Magness is a pioneer in optimizing organoid technologies, including 2D monolayer systems, 3D ‘gut-on-chip’ platforms, and high-throughput analysis. These models are used to study complex biological processes such as Cystic Fibrosis, IBD, and host-microbe interactions. His extensive research has led to numerous publications and earned him a Transformative R01 Award for creating a human intestinal simulacrum.
CGIBD Focus Area(s):Â Â Regeneration and Repair
Pilot and Feasibility Award 2011
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