Research Interests
My groups research is focused on identifying novel mechanisms responsible for pathological activation of coagulation and venous thromboembolism. Venous thromboembolism, including deep vein thrombosis and pulmonary embolism, is a common cardiovascular disease that is a major source of morbidity and mortality worldwide. The mechanisms that drive聽pathological activation of coagulation and聽venous thrombosis remain incompletely understood. We contend that a better understanding of these mechanisms will enable identification of at-risk populations and novel targets for the development of safe and effective anticoagulant drugs. A major focus of current efforts centers on the role of C1 inhibitor, a multifunctional serine protease inhibitor, as a negative regulator of pathological activation of coagulation. We have revealed novel associations between C1 inhibitor deficiency in humans, that causes the rare congenital swelling disorder Hereditary Angioedema, and increased contact pathway-mediated coagulation and risk of venous thromboembolism. Further, we have been able to model the procoagulant phenotype associated with Hereditary Angioedema in C1 inhibitor deficient mice. Additional research interests include evaluating the role of additional SERPINs and the complement factors in venous thrombosis.
Education and Experience
BSc: The University of Manchester, 2009
MRes: King鈥檚 College London, 2011
PhD: King鈥檚 College London, 2015
Postdoctoral Fellowship: Beth Israel Deaconess Medical Center & Harvard Medical School, 2015-2017
The University of North Carolina at Chapel Hill, 2017-2022
Research Assistant Professor: The University of North Carolina at Chapel Hill, 2022-Present
Selected Bibliography
Grover SP, Kawano T, Wan J, Tanratana P, Polai Z, Shim YJ, Snir O, Br忙kkan S, Dhrolia S, Kasthuri R, Bendapudi PK, McCrae KR, Wolberg AS, Hansen JB, Farkas H, Mackman N. . Blood. 2023: In Press.
Wan J, Tanratana P, Roest M, Gruber A, Pawlinski R, Wolberg AS, Mackman N, Grover SP. . Blood Advances. 2022; In Press
Grover SP, Sundler Bj枚rkman L, Egesten A, Moll S, Mackman N. . J Thromb Haemost. 2022; 20(11): 2703-2706
Grover SP, Olson TM, Cooley BC and Mackman N. . J Thromb Haemost. 2020;18(11):2899-2909.
Grover SP, Schmedes CM, Auriemma AC, Butler E, Parrish SL, Miszta A, Cleuren AC, Visser M, Heitmeier S, Posma JJ, Spronk HM, Antoniak S, Wolberg AS, Pawlinski R, Gailani D, Mackman N. . Blood Advances. 2020; 4(1): 207鈥�216.
Full bibliography available .
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