August 20, 2024
Steven Grover, PhD has been awarded an R01 from NIH NHLBI in the amount of $3,275,000 for a five-year project titled 鈥淩egulation of Coagulation and Thrombosis by C1-inhibitor鈥�. The award will fund translational studies to evaluate the procoagulant phenotype associated with congenital C1-inhibitor deficiency and the potential utility of FDA approved C1-inhibitor preparations as hemostasis …
August 2, 2024
August 2024 Newsletter
August 1, 2024
The new MPI R01 from the NIH NHLBI, entitled 鈥淩ole of Factor XII in Thrombo-Inflammatory Complications of Sickle Cell鈥�, was awarded to Rafal Pawlinski, PhD of University of North Carolina at Chapel Hill and to Evi Stavrou, MD of Case Western Reserve University. The four-year $3,129,000 project is proposed to study the mechanism of FXII …
July 18, 2024
“Blood coagulation factor IX: structural insights impacting hemophilia B therapy” was recently accepted for publication in the journal Blood. The work is a collaboration between BRC Center member Dougald Monroe and Leiden University Medical Center investigators Rianne Elaine van Diest and Mettine H A Bos. This review focuses on analyzing the structure of factor IX …
July 8, 2024
Yohei Hisada, Ph.D. awarded SOM Boost funding award from the Dean’s office. The Dean鈥檚 Office will provide proposal Mechanisms of coagulopathy and bleeding in acute promyelocytic leukemia with Boost funding. The Boost award will provide $25,000 to help sustain his project and obtain preliminary data during the resubmission and review process of R01 grant. 黑料网 …
July 2, 2024
The International Society on Thrombosis and Haemostasis (ISTH), an international medical and scientific professional Society advancing the understanding, prevention, diagnosis, and treatment of thrombosis and hemostasis, announces the ISTH 2024 Congress will be hosted in Bangkok, Thailand for the first time on June 22-26, 2024, at the Queen Sirikit National Convention Center. The ISTH Congress …
July 2, 2024
Melissa Caughey PhD received an NIH grant related to sickle cell disease: “Chronic dehydration in sickle cell disease: an actionable biomarker to prevent vaso-occlusive episodes” The National Institutes of Health is the largest public funder of biomedical research in the world. In fiscal year 2022, NIH invested most of its $45 billion appropriations in research …
June 10, 2024
A manuscript entitled 鈥淒isease severity drives thrombosis risk in women with sickle cell disease in a single-center retrospective study鈥� was recently accepted in Research and Practice in Thrombosis and Haemostasias. The research was initiated by Jennifer Light, MD, during her fellowship in the 黑料网 Pediatrics Division of Hematology and Oncology. She performed her basic research …
June 7, 2024
A new MPI NIH R01 was awarded to Alisa Wolberg, PhD and Karin Leiderman, PhD of University of North Carolina at Chapel Hill School of Medicine, entitled: 鈥淚nterdisciplinary Approach to Elucidate Modifiers of Bleeding Phenotype in Factor XI Deficiency.鈥� PROJECT SUMMARY Congenital聽deficiency聽of plasma clotting聽factor聽(F)XI聽is an autosomal disorder. Whereas some individuals are asymptomatic (non-bleeders), others have …
June 7, 2024
Jamie Madrigal, Mac Monroe, Suzanne Sindi, Karin Leiderman, from The University of North Carolina at Chapel Hill School of Medicine, had a new paper published in Mathematical Biosciences. 鈥淢odeling the Distribution of Enzymes on Lipid Vesicles: A Novel Framework for Surface-Mediated Reactions in Coagulation鈥�. Abstract Blood coagulation is a network of biochemical reactions wherein dozens …
June 5, 2024
Abigail Ballard-Kordeliski, Robert H. Lee, Ellen Clelia O’Shaughnessy, Paul Y. Kim, Summer R Jones, Rafal Pawlinski, Matthew J. Flick, David S. Paul, Nigel Mackman, David Adalsteinsson, Wolfgang Bergmeier all of University of North Carolina at Chapel Hill had their research published in the journal Blood. Title: “4D intravital imaging identifies platelets as the predominant …
May 28, 2024
May 2024 Newsletter