{"id":30096,"date":"2024-11-14T11:21:23","date_gmt":"2024-11-14T16:21:23","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/?post_type=directory&#038;p=30096"},"modified":"2025-05-21T10:18:23","modified_gmt":"2025-05-21T14:18:23","slug":"tigist-tamir","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/biochem\/directory\/tigist-tamir\/","title":{"rendered":"Tigist Tamir"},"content":{"rendered":"<p style=\"text-align: center\"><em><strong>Assistant Professor<br \/>\n<\/strong><\/em>(PhD &#8211; University of North Carolina at Chapel Hill)<br \/>\nMember of the Lineberger Comprehensive Cancer Center, Department of Nutrition, and Computational Medicine Program<\/p>\n<p style=\"text-align: center\"><strong>Accepting rotation students starting in Spring 2025<\/strong><\/p>\n<p class=\"x_MsoNormal\">Research: <span data-olk-copy-source=\"MessageBody\">Cancer metabolism, Obesity, Diabetes, Cell signaling, Metabolism, Redox homeostasis, Phosphoproteomics, Metabolomics, Mass spectrometry, Computational modeling, Biochemistry.<\/span><\/p>\n<h2>Honors &amp; Awards<\/h2>\n<ul>\n<li>NIGMS MOSAIC Postdoctoral Career Transition Award to Promote Diversity (K99\/R00), 2023<\/li>\n<li>Eddie Mendez Postdoctoral Scholar Symposium, Fred Hutch Cancer Center, 2023<\/li>\n<li>黑料网 Rising Star Program, Dept of Pharmacology, 黑料网-CH, 2023<\/li>\n<li>UVA Emerging Leaders in BME Symposium, Dept of BME, UVA, 2022<\/li>\n<li>Future Leaders in Biochemistry &amp; Biophysics Symposium, Dept of B&amp;B, U. Penn., 2022<\/li>\n<li>Burroughs Wellcome Fund \u2013 PDEP, 2021<\/li>\n<li>Leading Edge Fellow, 2021<\/li>\n<li>Convergence Scholar, MIT Center for Precision Cancer Medicine, Koch Institute, 2020<\/li>\n<li>HHMI Gilliam Fellowship, 2016<\/li>\n<\/ul>\n<h2>Research<\/h2>\n<p class=\"x_MsoNormal\">Research topics: Cell signaling, metabolism, redox homeostasis, phosphoproteomics, metabolomics, mass spectrometry, computational modeling, biochemistry.<b><\/b><\/p>\n<p class=\"x_MsoNormal\">Research summary: Determine how cellular signaling networks regulate oxidative stress response (OSR) and cellular homeostasis. The Tamir lab aims to decipher dysregulated OSR in diseases by utilizing integrative Omics, structural analysis, and computational modeling to evaluate regulatory signaling inputs that alter metabolism in obesity and cancer.<\/p>\n<p><strong>Systems Metabolism and Signaling Lab<\/strong><\/p>\n<p>Oxidative stress, a byproduct of energy production essential for all living organisms, arises from an imbalance of reactive oxygen, nitrogen, and carbonyl species (ROS\/RNS\/RCS). These highly reactive molecules present a significant waste management challenge within cells. Through evolution, oxidative stress response (OSR) pathways have emerged as critical guardian of cellular homeostasis, adept at neutralizing potentially harmful reactive molecules. Dysregulation of OSR\u2014whether due to insufficient or excessive capacity to resolve oxidative damage\u2014is a hallmark of numerous human diseases. For example, cancer cells co-opt OSR pathways by rewiring signaling and metabolism which leads to the development of resistance to chemotherapy.<\/p>\n<p>The Systems Metabolism and Signaling Lab (i.e. Tamir Lab) seeks to unravel the biochemical intricacies of how cells defend against oxidative stress by investigating the cell signaling-mediated regulation of metabolism. We aim to address fundamental questions about the biochemistry of OSR regulation, including:<\/p>\n<ul>\n<li>How is information transferred across biomolecules, from the phosphoproteome to the metabolome?<\/li>\n<li>What is the role of phosphorylation in shaping the structure and function of antioxidant enzymes?<\/li>\n<li>Where do cell signaling pathways intersect with metabolism during OSR?<\/li>\n<li>What are the signals driving dysregulated OSR in diseases?<\/li>\n<\/ul>\n<p>To tackle these questions, we employ a multidisciplinary approach that integrates biochemistry, proteomics, metabolomics, molecular biology, and systems biology. Our work focuses on dissecting the regulatory networks governing OSR and identifying targetable pathways implicated in obesity and cancer. As a member of the Lineberger Comprehensive Cancer Center, Department of Nutrition, and Computational Medicine Program, we bridge molecular insights with systems-level understanding as we strive to illuminate novel and effective strategies for therapeutic interventions. We will apply the fundamental knowledge in:<\/p>\n<ul>\n<li><strong>Obesity driven metabolic dysfunction and diabetes<\/strong> by asking how dietary supplement with antioxidants abrogate onset of insulin resistance.<\/li>\n<li><strong>In cancer cell metabolism<\/strong> by asking how signaling inputs on antioxidant enzymes alter systemic OSR and metabolic reprogramming to nominate potential vulnerabilities in treatment resistant cancers.<\/li>\n<\/ul>\n<p>Our approaches: machine learning, phosphoproteomics, metabolomics, computational structural modeling, biosensor-based high content screening, and CRISPR-based genome editing<\/p>\n<p>The Systems Metabolism and Signaling Lab is committed to fostering a collaborative, creative, and diverse group that is invested in mutual growth.<\/p>\n<h2>Biography<\/h2>\n<p>Dr. Tigist Tamir received her B.S. in Biology and Bio-Mathematics from the College of William and Mary, and her Ph.D. in Pharmacology from the University of North Carolina at Chapel Hill in Dr. Ben Major\u2019s lab. Her research focus is on identifying the convergence between cell signaling and metabolism. Dr. Tamir conducted her postdoctoral training in the laboratory of Dr. Forest White, at the Koch Institute for Integrative Cancer Research at MIT. In her present work, Dr. Tamir employs a multidisciplinary approach utilizing biochemistry, multi-omics, and computational models to investigate the intricate regulation of oxidative stress response within complex signaling and metabolic networks. She will be starting her research group, The Systems Metabolism and Signaling Lab, in the department of Biochemistry and Biophysics December 2024. Dr. Tamir is accepting applications for RA and postdoc positions, and will be accepting rotation students starting spring 2025.<\/p>\n<h2>Publications<\/h2>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/tigist.tamir.1\/bibliography\/public\/\">link <span data-olk-copy-source=\"MessageBody\">to all publications for Tigist Tamir<\/span><\/a><\/p>\n<hr \/>\n<p>Contact Information <a href=\"mailto:tytamir@med.unc.edu\">Email<\/a><\/p>\n<p>Office: 3046 Genetic Medicine Building<br \/>\nLab: 3049E and 3049F Genetic Medicine Building<br \/>\n120 Mason Farm Rd, CB 7260, Chapel Hill, NC 27599-7260<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Assistant Professor (PhD &#8211; University of North Carolina at Chapel Hill) Member of the Lineberger Comprehensive Cancer Center, Department of Nutrition, and Computational Medicine Program Accepting rotation students starting in Spring 2025 Research: Cancer metabolism, Obesity, Diabetes, Cell signaling, Metabolism, Redox homeostasis, Phosphoproteomics, Metabolomics, Mass spectrometry, Computational modeling, Biochemistry. Honors &amp; Awards NIGMS MOSAIC Postdoctoral &hellip; <a href=\"https:\/\/www.med.unc.edu\/biochem\/directory\/tigist-tamir\/\" aria-label=\"Read more about Tigist Tamir\">Read more<\/a><\/p>\n","protected":false},"featured_media":30187,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-30096","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Tigist Tamir | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/directory\/tigist-tamir\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tigist Tamir | Biochemistry and Biophysics\" \/>\n<meta property=\"og:description\" content=\"Assistant Professor (PhD &#8211; University of North Carolina at Chapel Hill) Member of the Lineberger Comprehensive Cancer Center, Department of Nutrition, and Computational Medicine Program Accepting rotation students starting in Spring 2025 Research: Cancer metabolism, Obesity, Diabetes, Cell signaling, Metabolism, Redox homeostasis, Phosphoproteomics, Metabolomics, Mass spectrometry, Computational modeling, Biochemistry. 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