Chair & Professor of Biochemistry and Biophysics
Pharmacology – a joint appointment
Community and Engagement Committee Member, Community Outreach
(PhD – University of California, Berkeley)
Accepting Rotation Students
HONORS & AWARDS
- W. M. Keck Foundation Award, 2015
- Academy of Educators Elected Fellow, 2012
- The Jefferson-Pilot Fellowship in Academic Medicine, 2010-2014
- Academy of Educators Teaching Excellence Award, 2010
- National Cancer Institute’s Howard Temin Award, 2003-2008
RESEARCH
Cell Cycle Control in Human Cells
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Our lab studies the regulation of the mammalian cell cycle with a particular focus on the cell cycle phase transitions related to DNA replication and to cell cycle exit.
Cells coordinate progression through the cell division cycle with a wide variety of extracellular and intracellular information by regulating the activity and abundance of key cell cycle proteins.
Many proteins have more than one function in the cell cycle, and one of our goals is to understand how those different functions are integrated to preserve normal cell proliferation.
We manipulate cell cycle proteins in human cell lines using a variety of molecular genetic tools. We deplete proteins from cells using siRNA techniques, overproduce proteins using recombinant plasmid or viral vectors, and inhibit activities with pharmacological reagents. New projects employ live cell imaging and single cell analysis of protein abundance during the cell cycle. Ultimately we hope to achieve a greater understanding of normal cell cycle control so that future therapeutic tools related to regeneration and cancer treatment can be developed.
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For more detailed information, as well as an introduction to the members of the Cook lab, visit our webpage:
CORE TECHNIQUES
- cell proliferation dynamics
- genome stability control
- molecular biology
- quantitative single cell analysis
PUBLICATIONS
Lab Contact:
Lab Rooms: 3070G-H Genetic Medicine
Lab Phone: 919-966-3935
